Age-specific sex difference in the incidence of hepatocellular carcinoma in the United States
نویسندگان
چکیده
BACKGROUND Hepatocellular carcinoma possesses a notable sex difference in incidence, and a protective role of estrogens has been hypothesized. METHODS Using data from 13 cancer registries in the Surveillance, Epidemiology, and End Results Program, we describe the age-specific sex difference in the incidence of hepatocellular carcinoma in the United States during 1992-2013. We used a curve fitting by non-linear regression to quantitatively characterize the age-specific incidence rate of hepatocellular carcinoma by sex. RESULTS A total of 44,287 incident cases of hepatocellular carcinoma (33,196 males and 11,091 females) were included, with an overall male-to-female ratio in age-standardized rate of 3.55. The sex ratio was below 2 at ages <25 years, increased with age from ages 25-29 years until peaking at 5.40 at ages 50-54 years, and declined thereafter. We also observed additional peaks in the age-specific sex ratio curves at ages 25-34 years across racial/ethnic groups. Modelling of age-specific incidence rates indicated a 15-year delayed increase with age in females compared with males in Asian and Pacific Islanders, and an 11-year delay in Hispanic whites. CONCLUSIONS The age-dependent patterns in the sex difference in the incidence of hepatocellular carcinoma support the hypothesis of a protective role of estrogens. The underlying reasons for the sex difference in hepatocellular carcinoma remain to be further explored in analytic epidemiological studies.
منابع مشابه
The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update.
BACKGROUND The incidence of hepatocellular carcinoma was reported to be increasing in the United States. However, alternate explanations were diagnostic or reclassification bias and changes in the demographic features of the general population. OBJECTIVE To examine the temporal trends in the incidence of hepatocellular carcinoma. DESIGN Retrospective cohort study. SETTING Information coll...
متن کاملتعیین میزان آنتیبادی ضدّ ویروس هپاتیت B درکارکنان پرستاری دانشگاه علوم پزشکی بیرجند
Background and Aim: Hepatitis B virus is the cause of acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Its prevalence has been reported to be 0.1%-0.5% and 1.6%-6.5% in the United States and Iran respectively. At present, the only sure preventive measure is vaccination but it does not create absolute (100%) immunity. Antibody production is between 79% to 90%, which occurs t...
متن کاملBasal cell carcinoma in patients referred to Imam Khomeini Hospital in Ahwaz in 1366-76
Background: Basal cell carcinoma (BCC) is the most common skin cancer in humans showing various clinical and histological forms. Objective: The aim of this study was to evaluate the age, sex, location, histological subtypes of BCC cases in Ahwaz and to compare it with other skin cancers specially squamous cell carcinoma. Patients and Methods: A descriptive, retrospective study was done using fi...
متن کاملComparing Mental and Physical Health of Full-Service Sex Workers in the United States to the Health of the General Population in 2019-2020
Introduction: Full-service sex workers (FSSWs) are relatively prevalent in the U.S. and are known to face criminalization, stigma, and other factors relating to poor health. The main aim of this study was compare the mental and physical health of full-service sex workers in the United States in 2019-2020 Methods: In this prospective cohort study, participants were recruited through national c...
متن کاملIncidence of incomplete excision in surgically treated basal cell carcinomas and identification of the related risk factors
Background: Surgery is the most frequent treatment modality for basal cell carcinoma but in spite of its high cure rate, the frequency of incomplete excision varies widely (0.7-50%) among dermatologic centers. Our case series was designed to determine the frequency of incompletely excised basal cell carcinoma and the related risk factors. Methods: A total of 1424 basal cell carcinoma (1040 pati...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2017